Prof Sheila MacNeil


Photograph of Professor Sheila MacNeil

Sheila MacNeil is Professor of Tissue Engineering in the Department of Materials Science and Engineering, joining the department in 2000. She has an undergraduate degree in physiology from the University of Aberdeen and a doctorate on the endocrinology of manic depression from the Medical School of the University of Sheffield.

She is academic lead of the Biomaterials and Tissue Engineering Group within the Department. Members of this group: Professor John Haycock, Readers Dr Ihtesham Rehman, Senior Lecturers Dr Frederik Claeyssens, Dr Gwen Reilly, Lecturer Dr Vanessa Hearnden and Research Fellow Dr Nicola Green.

She has previously been Deputy Director of the Kroto Research Institute (from 2005 to 2009) and Director of the University Centre for Biomaterials and Tissue Engineering from 2002 to 2009, promoting interdisciplinary research between engineering, physical sciences and life sciences. She was also a founding Director of the University of Sheffield spin-out company, CellTran Limited from 2000 to 2007 which developed the product Myskin™ which is used by burns centres throughout the UK.

Her research focuses on the development of tissue engineered skin and other epithelial tissues (oral mucosa, oesophagus, bladder, pelvic floor and cornea) and has successfully developed tissue engineered skin products through to commercialisation (MySkin™ and Cryoskin™)  to benefit patients with severe burns and chronic wounds.  Recent tissue engineering challenges include development of scaffolds for repair of the female pelvic floor, biomaterials to deliver corneal cells to patients and development of hybrid biomaterials for cleft palate repair.  She seeks to translate clinical benefit for patients by working closely with clinical colleagues in Burns, Dermatology and Urology.  She is working with colleagues in India to develop an alternative to the amniotic membrane for transplantation of corneal limbal stem cells for patients with scarring of the cornea.

She led a team of academic staff which established a cross faculty BEng, MEng in Bioengineering  in 2011, which received accreditation in 2014.

Sheila recently featured in the global dissemination publication; International Innovation. You can view the article here.

Key projects

Her current projects include simplifying the challenge of corneal regeneration (working with colleagues in LV Prasad Eye Institute, Hyderabad, India with Wellcome funding).  This study has now entered into a first-in-man clinical safety study in India.  She is developing biomaterials for repair of the weakened tissues of the pelvic floor (with Prof Chris Chapple, Consultant Urologist, Sheffield Teaching Hospitals).  She is also working on approaches for repairing burns contractures and scarring using a one-stage approach to combining patient’s tissues with an instructional biodegradable synthetic scaffold. She also has funding on early detection of infection in the cornea (with Prof Steve Rimmer in Chemistry, University of Bradford and Prof Ian Douglas in Sheffield) and is part of two funded networks on developing alternative approaches to the use of antibiotics to tackle bacterial infection (one with India funded through MRC-DBT and one in the UK funded by EPSRC).

Group members

Post Doctoral Research Associates

Dr Anthony J Bullock
Dr Sabiniano Roman
Dr Natalya Doroshenko
Dr Ahtasham Raza
Dr Rahaf Issa


Marcela Garcia Martinez
Samand Pashneh-Tala
Serkan Dikici

Clinical Research Fellows

Kavita Sharma
Naside Mangir

Research Interests

Tissue Engineering
Biomaterials for soft tissue repairs
Clinical Translation

External links

Key Papers Prior to 2010 [with number of citations]

Bhargava S, Patterson J, Inman RD, MacNeil S and Chapple CR. Tissue engineered buccal mucosa urethroplasty – clinical outcomes. European Urology 53(6):1263-1271.  (2008)  (doi: 10.1016/j.eururo.2008.01.061) [98]

Blackwood K, McKean R, Canton I, Freeman C, Franklin K, Cole D, Brook I, Farthing P, Rimmer S, Haycock JW, Ryan AJ and MacNeil. Development of biodegradable electrospun scaffolds for dermal replacement. Biomaterials 29(21):3091-3104. (2008) (doi: 10.1016/j.biomaterials.2008.03.037) [113]

MacNeil S. Progress and Opportunities in Tissue Engineering of Skin. Nature Insights. Nature 445, 874-880 (2007) (doi: 10.1038/nature05664) [332]

Sun T, Jackson S, Haycock JW and MacNeil S. Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. Biotechnology 122:372-381.  (2006) (doi: 10.1016/j.jbiotec.2005.12.021[96]

Sun T, Mai S, Norton D, Haycock JW, Ryan AJ and MacNeil S. Self-organisation of Skin Cells in 3D-Electrospun Polystyrene Scaffolds. Tissue Engineering 11:1023-1033. (2005) (doi: 10.1089/ten.2005.11.1023) [93]

Haddow DB, Steele DA, Short RD, Dawson RA and MacNeil S. Plasma polymerised surfaces for culture of human keratinocytes and transfer of cells to an in vitro wound bed model. Journal of Biomedical Materials Research 64A:80-87. (2003) (doi: 10.1002/jbm.a.10356[70]

Ghosh MM, Boyce SG, Layton C, Freedlander E and MacNeil S. A comparison of methodologies for the preparation of human epidermal/dermal composites. Plast. Surg 39:390-404. (1997) (Ann Plast Surg. 1997 Oct;39(4):390-404[75]

Publications (2010 to date)

Narice B, Green NH, MacNeil S, Anumba D. Second Harmonic Generation microscopy reveals collagen fibres are more organised in the cervix of postmenopausal women. Reproductive Biology and Endocrinology (2016) 14:70 (doi: 10.1186/s12958-016-0204-7)

Bostan LE, Taylor ZA, Carre MJ, MacNeil S, Franklin SE, Lewis R. A Comparison of Friction behaviour for ex vivo Human, Tissue Engineered and Synthetic Skin. Tribology International (Available online) (2016).  (doi: doi:10.1016/j.triboint.2016.07.023)

Harvey AC, Madsen J, Douglas CW, MacNeil S, Armes SP.  Antimicrobial graft copolymer gels. Biomacromolecules (2016) [Epub ahead of print] (doi: 10.1021/acs.biomac.6b00760)

Ventress JK, Partridge LJ, Read RC, Cozens D, MacNeil S, Monk PN. Peptides from Tetraspanin CD9 Are Potent Inhibitors of Staphylococcus Aureus Adherence to Keratinocytes. PLOS One 2016 (doi: 10.1371/journal.pone.0160387)

Puwanun S, Bye FJ, Ireland MM, MacNeil S, Reilly GC, Green NH. Production and characterization of a novel, electrospun, tri-layer polycaprolactone membrane for the segregated co-culture of bone and soft tissue. Polymers 8(6):221 (2016) (doi: 10.3390/polym8060221)

Sharif F, Rehman IU, Muhammad N, MacNeil S. Dental materials for cleft palate repair. Materials science & engineering. 61:1018-1028 (2016) (doi: 10.1016/j.msec.2015.12.019)

Tse C, Whitely R, Yu T, Stringer J, MacNeil S, Haycock JW, Smith PJ. Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication, Volume 8, Number 1 (2016) (doi: 10.1088/1758-5090/8/1/015017)

Roman S, Mangir N, Bissoli J, Chapple CR, MacNeil S. Biodegradable scaffolds designed to mimic fascia-like properties for the treatment of pelvic organ prolapse and stress urinary incontinence. Journal of Biomaterials Applications (2016) (doi: 10.1177/0885328216633373)

Roman S, Urbánková I, Callewaert G, Lesage F, Hillary C, Osman NI, Chapple CR, Deprest J, MacNeil S. Evaluating alternative materials for the treatment of stress urinary incontinence and pelvic organ prolapse – a comparison of the in vivo response to meshes of polypropylene, polyvinylidene fluoride, poly-lactic acid and polyurethane implanted in rabbits for 3 months. Journal of Urology (2016) (doi: 10.1016/j.juro.2016.02.067)

Hillary CJ, Roman S, Bullock AJ, Green NH, Chapple CR, MacNeil S. Developing repair materials for stress urinary incontinence to withstand dynamic distension. PLOS ONE (2016) (doi: 10.1371/journal.pone.0149971)

Yar M, Gigliobianco G, Shahzadi L, Dew L, Siddiqi SA, Khan AF, Chaudhry AA, Rehman IU, MacNeil S. Production of chitosan PVA PCL hydrogels to bind heparin and induce angiogenesis. International Journal of Polymeric Materials. 65(9): 466-476 (2016) (doi: 10.1080/00914037.2015.1129959)

Yorucu C, Lau K, Mittar S, Green NH, Raza A, Rehman IU, MacNeil S. Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. Applied Spectroscopy Reviews 51(4): 243-157 (2016) (doi: 10.1080/05704928.2015.1126840)

Mangir N, Bullock AJ, Roman S, Osman N, Chapple C, MacNeil S.  Production of ascorbic acid releasing biomaterials for pelvic floor repair. Acta Biomaterialia. 29:188-197 (2016) (doi: 10.1016/j.actbio.2015.10.019)

Tse CCW, Ng SS, Stringer J, MacNeil S, Haycock JW, Smith PJ. Utilising inkjet printed paraffin wax for cell patterning applications.  International Journal of Bioprinting. vol.2(1): (2015)

Osman NI, Chapple CR, MacNeil S. Re: Guido Barbagli, Massimo Lazzeri. Clinical Experience with Urethral Reconstruction Using Tissue-engineered Oral Mucosa: A Quiet Revolution. Eur Urol. 68(5): E99-E100 (2015) (doi: 10.1016/j.eururo.2015.05.043)

Frydrych M, Roman S, Green NH, MacNeil S, Chen B. Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6, 7974 – 7987 (2015) (doi: 10.1039/C5PY01136A)

Roman S, Bullock AJ, Anumba DO, MacNeil S. Development of an implantable synthetic membrane for the treatment of preterm premature rupture of fetal membranes.  Journal of Biomaterials Applications. 1-9 (2015). (doi: 10.1177/0885328215612500)

Pashneh-Tala S, MacNeil S, Claeyssens F.  The tissue-engineered vascular graft – past, present and future.  Tissue Engineering Part B. doi: 10.1089/ten.teb.2015.0100 (2015)

Justin R, Roman S, Chen D, Tao K, Geng X, Grant RT, MacNeil S, Sun K, Chen B. Biodegradable and conductive chitosan-graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics. RSC Advances. 5(64):51934-51946 (2015) (doi: 10.1039/C5RA04340A)

Green NH, Corfe BM, Bury JP, MacNeil S.  Production, characterisation and potential uses of a 3D tissue-engineered human oesophageal mucosal model. Journal of Visualised Experiments (JoVE). 99:e52693 (2015) (doi: 10.3791/52693)

Frydrych M, Roman S, MacNeil S, Chen B. Biomimetic poly(glycerol sebacate)/poly(L-lactic acid) blend scaffolds for adipose tissue engineering.  Acta Biomaterialia. 18:40-49 (2015) (doi: 10.1016/j.actbio.2015.03.004)

Chapple CR, Osman NI, Mangera A, Hillary C, Roman S, Bullock A, MacNeil S.  Application of tissue engineering to pelvic organ prolapse and stress urinary incontinence. LUTS 7: 63-70 (2015) (doi: 10.1111/luts.12098)

MacNeil S. Can you whistle? Then I’ll come: stem cells home to where they’re needed. British Journal of Dermatology (2015) 172: 1183-1184 (2015) (doi: 10.1111/bjd.13733)

Boadi J, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill MH, Murdoch C, Hunter KD, Matcher SJ.  Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography. SТМ. 7(1): 60-68. (doi: 10.17691/stm2015.7.1.08)

Deshpande P, Ortega I, Sefat F, Sangwan VS, Green N, Claeyssens F, MacNeil S. Rocking media over ex vivo corneas improves this model and allows the study of the effect of proinflammatory cytokines on wound healing. Invest Ophthalmol Vis Sci. 56(3):1553-61. 2015 (doi: 10.1167/iovs.14-15308)

Gigliobianco G, Chong CK, MacNeil S. Simple surface coating of  electrospun poly(L)lactic acid scaffolds to induce angiogenesis. Journal of Biomaterials Applications. 30(1):50-60 (2015). doi: 10.1177/0885328215569891)

Dew L, MacNeil S, Chong CK.  Vascularization Strategies for Tissue Engineers. Regenerative Medicine. 10(2): 211-244 (2015) (doi: 10.2217/rme.14.83)

Ortega I, Dew L, Kelly AG, Chong CK, MacNeil S, Claeyssens F.  Fabrication of biodegradable synthetic perfusable vascular networks via a combination of electrospinning and robocasting.  Biomaterials Science. 3(4):592-596 (2015) (doi: 10.1039/C4BM00418C)

Gigliobianco G, Roman S, Osman NI, Bissoli J, Bullock AJ, Chapple CR, MacNeil S.  Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?  Biomed Research International. 2015:96807  (2014) (doi: 10.1155/2015/968087)

Roman S, Albersen M, Manodoro S, Zia S, Osman NI, Bullock AJ, Chapple CR, Deprest J, MacNeil S. Acute In Vivo Response to an Alternative Implant for Urogynecology BioMed Research International 2014:1-10 (2014). (doi: 10.1155/2014/853610)

Sharma K, MacNeil S. Response to Letter to the Editor: ‘Construction of skin substitutes using minced split-thickness autografts and biodegradable synthetic scaffolds’. Burns 40(6): 1233-1234. (2014) (doi: 10.1016/j.burns.2014.01.016

Sharma K, Bullock A, Ralston D, MacNeil S. Development of a one-step approach for the reconstruction of full thickness skin defects using minced split thickness skin grafts and biodegradable synthetic scaffolds as a dermal substitute.  Burns 40(5):957-965 (2014). (doi: 10.1016/j.burns.2013.09.026)

Sarker P, Swindells K, Douglas CWI, MacNeil S, Rimmer S, Swanson L. Forster resonance energy transfer confirms the bacterial-induced conformational transition in highly-branched poly(N-isopropyl acrylamide with vancomycin end groups on binding to Staphylococcus aureus. Soft matter 10(31):5824-35 (2014). (doi: 10.1039/c4sm00056k)

Osman N. Long-term follow-up after tissue engineered buccal mucosa urethroplasty.  European Urology.  66(1):790-791 (2014). (doi: 10.1016/j.eururo.2014.07.007)

Easton C, Bullock AJ, Gigliobianco G, McArthur S, MacNeil S.  Application of Layer-By-Layer Coatings to Tissue Scaffolds – Development of a Pro-Angiogenic Biomaterial.  Journal of Materials Chemistry B. 2:5558-5568  (2014). (doi: 10.1039/C4TB00448E)

Osman N, Roman S, Bullock A, Chapple C, MacNeil S.  The effect of ascorbic acid and fluid flow stimulation on the mechanical properties of a tissue engineered pelvic floor repair material. Journal of Engineering in Medicine. 228(9): 867-875 (2014) (doi: 10.1177/0954411914549393)

Bye FJ, Bullock AJ, Singh R, Sefat F, Roman S, MacNeil S.  Development of a basement membrane substitute incorporated into an electrospun scaffold for 3D skin tissue engineering. Journal of Biomaterials and Tissue Engineering. 4(9) 686-692 (2014). (doi: 10.1166/jbt.2014.1224)

Hamilton N, Bullock AJ, MacNeil S, Janes SM, Birchall M.  Tissue engineering airway mucosa: a systematic review. Laryngoscope.  124(4):961-968 (2014). (doi: 10.1002/lary.24469)

Colley HE, Hearnden V, Avila-Olias M, Cecchin D, Canton I, Madsen J, MacNeil S, Warren N, Hu K, McKeating JA, Armes SP, Murdoch C, Thornhill MH, Battaglia G.  Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation.  Molecular Pharmaceutics. 11(4): 1176-1188 (2014). (doi: 10.1021/mp400610b)

Shahbuddin M, Bullock AJ, MacNeil S, Rimmer S.  Glucomannan-poly(N-vynyl pyrrolidinone) bicomponent hydrogels for wound healing.  Journal of Materials Chemistry B. 2(6):727-738 (2014). (doi: 10.1039/C3TB21640C)

Green NH, Nichols Z, Heath P, Cooper-Knock J, Corfe B, MacNeil S, Bury, J. Pulsatile Exposure to Simulated Reflux Leads to Changes in Gene Expression in a 3D Model of Oesophageal Mucosa.  IJEP 95(3) 216-228 (2014) (doi: 10.1111/iep.12083)

Hassan E, Deshpande P, Claeyssens F, Rimmer S, MacNeil S. Amine functional hydrogels as selective substrates for corneal epithelialisation.  Acta Biomaterialia 10(7):3029–3037 (2014) (doi: 10.1016/j.actbio.2014.02.043)

Delaine-Smith RM, Green NH, Matcher SJ, MacNeil S, Reilly G.  Monitoring fibrous scaffold guidance of three-dimensional collagen organisation using minimally-invasive second harmonic generation.  PLOS ONE. 9(2):e89761 (2014). (doi: 10.1371/journal.pone.0089761)

Ortega I, Sefat F, Deshpande P, Paterson T, Ramachandra C, Ryan AJ, MacNeil S, Claeyssens F. Combination of microstereolithography and electrospinning to produce membranes equipped with niches for corneal regeneration. Journal of visualized experiments  (JoVE) 91: e51826  (2014) (doi: 10.3791/51826)

Pegoraro C, Cecchin D, Madsen J, Warren N, Armes SP, MacNeil S, Lewis A, Battaglia G.  Translocation of flexible polymersomes across pores at the nanoscale.  Biomaterials Science. 2(5):680-692 (2014) (doi: 10.1039/C3BM60294J)

Ortega I, McKean R, Ryan AJ, MacNeil S, Claeyssens F.  Characterisation and evaluation of the impact of microfabricated pockets on the performance of limbal epithelial stem cells in biodegradable PLGA membranes for corneal regeneration.  Biomaterials Science. 2(5):723-734 (2014). (doi: 10.1039/C3BM60268K)

Sangwan VSS, Jain R, Basu S, Bagadi AB, Sureka S, Mariappan I, MacNeil S.  Transforming ocular surface stem cell research into successful clinical practice. Indian Journal of Ophthalmology.  62(1):29-40 (2014). (doi: 10.4103/0301-4738.126173)

Roman S, Mangera A, Osman NI, Bullock AJ, Chapple CR, Macneil S. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse – which cell source? Neurourol Urodyn.33(5):531-7 (2014) (doi: 10.1002/nau.22443)

Deshpande P, Ramachandran C, Sangwan VS, MacNeil S.  Cultivation of limbal epithelial cells on electrospun poly (lactide-co-glycolide) scaffolds for delivery to the cornea. Methods in Molecular Biology. 1014:179-185 (2013). (doi: 10.1007/978-1-62703-432-6_12)

Chau DYS, Johnson C, MacNeil S, Haycock JW, Ghaemmaghami A. The development of a 3D immunocompetent model of human skin. Biofabrication. 5(3):UNSP035011 (2013).doi: 10.1088/1758-5082/5/3/035011)

Deshpande P, Ralston DR, MacNeil S.  The use of allodermis prepared for Euro skin bank to prepare autologous tissue engineered skin for clinical use.  Burns. 39(6):1170-1177 (2013). (doi: 10.1016/j.burns.2013.02.011)

Sefat F, McKean R, Deshpande P, Ramachandra C, Hill CJ, Sangwan VS, Ryan AJ, MacNeil S.  Production, sterilisation and storage of biodegradable electrospun PLGA membranes for delivery of limbal stem cells to the cornea. Procedia Engineering. 59:101-116 (2013) (doi: 10.1016/j.proeng.2013.05.099)

Marques CMG, Dibden C, Danson S, Haycock JW, MacNeil S.  Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications. 3:175-189 (2013) (doi: 10.4236/jcdsa.2013.33028)

Bye FJ, Bissola J, Black L, Bullock AJ, Puwanun S, Moharamzadeh K, Reilly GC, Ryan AJ, MacNeil S.  Development of bilayer and trilayer nanofibrous/microfibrous scaffolds for regenerative medicine.  Biomater. Sci. 1:942-951 (2013) (doi: 10.1039/C3BM60074B)

Shahbuddin M, Shahbuddin D, Bullock AJ, Ibrahim H, Rimmer S, MacNeil S.  High molecular weight plant heteropolysaccharides stimulate fibroblasts but inhibit keratinocytes.  Carbohydrate Research.  375(28):90-99 (2013) (doi: 10.1016/j.carres.2013.04.006)

Li X, Upadhyay AK, Bullock AJ, Dicolandrea T, Xu J, Binder RL, Robinson MK, Finlay DR, Mills KJ, Bascom CC, Kelling CK, Isfort RJ, Haycock JW, MacNeil S, Smallwood R.  Skin stem cell hypotheses and long term clone survival – explored using agent based modelling. Scientific Reports. 3. 1904 (2013). (doi: 10.1038/srep01904)

Chapple C, Osman N, MacNeil S.  Developing tissue engineered solutions for the treatment of extensive urethral strictures.  European Urology. 63(3): 539-541 (2013) (doi: 10.1016/j.eururo.2012.09.046)

Ortega I, Ryan AJ, Deshpande P, MacNeil S, Claeyssens F.  Combined microfabrication and electrospinning to produce 3-D architectures for corneal repair.  Acta Biomaterialia. 9(3):5511-5520 (2013) (doi: 10.1016/j.actbio.2012.10.039)

Osman NI, Roman S, Gigliobianco S, Mangera A, Bullock AJ, Chapple CR, MacNeil S.  Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse: comment on Boennelycke et al.  International Urogynecology Journal.  24(4):881 (2013) (doi: 10.1007/s00192-012-2023-5)

Ortega I, Deshpande P, Gill A, MacNeil S, Claeyssens F.  Development of a microfabricated artificial limbus with micropockets for cell delivery to the cornea.  Biofabrication. 5(2):025008 (2013). (doi: 10.1088/1758-5082/5/2/025008)

Deshpande P, Ramachandran C, Sefat F, Mariappan I, Johnson C, McKean R, Hannah M, Sangwan VS, Claeyssens F, Ryan AJ, MacNeil S.  Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants.  Biomaterials. 34(21): 5088-5106 (2013) (doi: 10.1016/j.biomaterials.2013.03.064)

Mangera A, Bullock AJ, Roman S, Chapple CR, MacNeil S. A comparison of candidate scaffolds for tissue engineering for stress urinary incontinence and pelvic organ prolapse repair.  BJU International. 112(5):674-85 (2013). (doi: 10.1111/bju.12186)

Pegoraro C, Cecchin D, Gracia LS, Warren N, Madsen J, Armes SP, Lewis A, MacNeil S, Battaglia G.  Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes. Cancer Lett. 334(2):328-337 (2013). (doi: 10.1016/j.canlet.2013.02.007)

Jiang D, Qi Y, Walker NG, Sindrilaru A, Hainzl A, Wlaschek M, MacNeil S, Scharffetter-Kochanek K. The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing.  Biomaterials. 34(10):2501-15 (2013) (doi: 10.1016/j.biomaterials.2012.12.014)

Gilmore L, Rimmer S, McArthur SL, Mittar S, Sun D, MacNeil S.  Arginine functionalisation of hydrogels for heparin binding – a supramolecular approach to developing a pro-angiogenic biomaterial Biotechnol Bioeng. 110(1):296-317  (2013) (doi: 10.1002/bit.24598)

Zhang Y, Tse C, Rouholamin D, Smith PJ. Scaffolds for tissue engineering produced by inkjet printing. Central European Journal of Engineering. 2(3): 325-335 (2012). (doi: 10.2478/s13531-012-0016-2)

Chapple CR, MacNeil S.  Tissue engineered oral mucosa for urethroplasty: Past experience and future directions. Journal of Urology. 187(5):1533-1534 (2012) (doi: 10.1016/j.juro.2012.01.084)

Toor GS, Basu S, MacNeil S, Sangwan VS. Successful deep anterior lamellar keratoplasty following multiple failed limbal transplantations for chronic ocular burns. BMJ Case Reports. 2012: (2012). (doi: 10.1136/bcr-2012-006774)

Delaine-Smith RM, MacNeil S, Reilly GC.  Matrix production and collagen structure are enhanced in two types of osteogenic progenitor cells by a simple fluid shear stress stimulus. European cells & materials  24:162-74 (2012) (Delaine-Smith 2012)

Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH, MacNeil S.  Tissue-engineered Oral Mucosa.  Journal of Dental Research. 91(7):642-650   (2012). (doi: 10.1177/0022034511435702)

Osman NI, Mangera A, Roman S, Bullock AJ, MacNeil S, Chapple CR. Mesh Social Networking: A patient-driven process. BJU International. 109(12): E45-E46 (2012) (doi: 10.1111/j.1464-410X.2012.11235_3.x)

Bye FJ, Wang L, Bullock AJ, Blackwood KA, Ryan AJ, MacNeil S.  Postproduction Processing of Electrospun Fibres for Tissue Engineering. Journal of Visualized Experiments: JoVE. 66: e4172, DOI: 10.3791/4172 (2012). ( (doi: 10.3791/4172)

Pegoraro C, MacNeil S, Battaglia G. Transdermal drug delivery: from micro to nano.  Nanoscale. 4(6):1881-1894. (2012) (doi: 10.1039/c2nr11606e)

Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. British Journal of Ophthalmology. 96(7):931-4. (2012) (doi: 10.1136/bjophthalmol-2011-301164)

Holcombe M, Adra S., Bicak M, Chin S, Coakley S, Graham AI, Green J, Greenough C, Jackson D, Kiran M, MacNeil S, Maleki-Dizaji A, McMinn P, Pogson M, Poole R, Qwarnstrom E, Ratnieks F, Rolfe MD, Smallwood R, Sun T, Worth D. Modelling Complex Biological Systems Using an Agent-based Approach. Integrative Biology. 4(1):53-64. (2012) (doi: 10.1039/C1IB00042J)

Walker NG, Mistry AR, Smith LE, Eves PC, Tsaknakis G, Forster S, Watt SM, MacNeil S. A Chemically-defined Carrier for the Delivery of Human Mesenchymal Stem/Stromal Cells to Skin Wounds. Tissue Engineering. 18(2):143-55 (2012) (doi: 10.1089/ten.TEC.2011.0037)

Smith LE, Hearnden V, Lu A, Smallwood R, Hunter KD, Matcher SJ, Thornhill MH, Murdoch C, MacNeil S.  Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro. Journal of Biomedical Optics.  16(11):116015 (2011) (doi: 10.1117/1.3652708)

Green NH, Huang Q, Corfe BM, Bury JP, MacNeil S; NF-kappa B is activated in oesophageal fibroblasts in response to a paracrine signal generated by acid-exposed primary oesophageal squamous cells. International Journal of Experimental Pathology. 92(5): 345-356. (2011). (doi: 10.1111/j.1365-2613.2011.00778.x)

MacNeil S, Bains S, Johnson C, Idee JM, Factor C, Jestin G, Fretellier N, Morcos SK. Gadolinium Contrast Agent Associated Stimulation of Human Fibroblast Collagen Production. Investigative Radiology. 46(11):711-717.  (2011) (doi: 10.1097/RLI.0b013e31822b1f38)

Poole J, MacNeil S, Rimmer S.  Semicontinuous Emulsion Polymerization of Butyl Methacrylate and 1, 3-Butadiene in the Presence of Cyclodextrins and Cytocompatibility of Dicarboxylic Acid Telechelic Oligo(butyl Methacrylate)s Derived from Ozonolysis of the Latexes.  Macromolecular Chemistry & Physics.  212(18):2043-2051 (2011) (doi: 10.1002/macp.201100212)

Colley HE, Hearnden V, Jones AV, Weinreb PH, Violette SM, MacNeil S, Thornhill MH, Murdoch C.  Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma. British Journal of Cancer. 105(10):1582-1592 (2011) (doi: 10.1038/bjc.2011.403)

Fiorica C, Senior RA, Pitarresi G, Palumbo FS, Giammona G, Deshpande P, MacNeil S. Biocompatible hydrogels based on hyaluronic acid crosslinked with a polyaspartamide derivative as delivery systems for epithelial limbal cells. International Journal of Pharmaceutics. 414(1-2):104-111 (2011) (doi; 10.1016/j.ijpharm.2011.05.002)

Ma A, Zhao B, Bentley AJ, Brahma , MacNeil S, Martin FL, Rimmer S, Fullwood NJ. Corneal epithelialisation on surface-modified hydrogel implants. J Mater Sci: Mater Med. 22(3):663-670 (2011) (doi: 10.1007/s10856-011-4244-4)

Eves PC, Baran M, Bullet NA, Way L, Haddow D and MacNeil S. Establishing a transport protocol for the delivery of melanocytes and keratinocytes for the treatment of vitiligo.  Tissue Eng Part C Methods. 17(4):375-82 (2011) (doi: 10.1089/ten.TEC.2010.0221)

Shepherd J, Sarker P, Rimmer S, Swanson L, MacNeil S and Douglas I. Hyperbranched poly(NIPAM) polymers modified with antibiotics can both bind bacteria and reduce Gram-negative and Gram-positive bacterial burden in infected human tissue engineered skin. Biomaterials. 32(1):258-267 (2011). (doi: 10.1016/j.biomaterials.2010.08.084)

Krajewska E, Lewis C, Staton C, MacGowan A and MacNeil S.  New insights into induction of early-stage neovascularization in an improved tissue-engineered model of psoriasis.  J Tissue Eng Regen Med.;5(5):363-74 (2011) (doi: 10.1002/term.322)

Selim M, Bullock AJ, Blackwood KA, Chapple CR and MacNeil S.  Developing biodegradable scaffolds for tissue engineering of the urethra.  BJU International. 107(2):296-302 (2011). (doi: 10.1111/j.1464-410X.2010.09310.x)

Xie D, Huang H, Blackwood K, MacNeil S.  A novel route for the production of chitosan/poly(lactide-co-glycolide) graft copolymers for electrospinning.  Biomedical Materials. 5(6):065016 (2010) (doi: 10.1088/1748-6041/5/6/065016)

Hearnden V, Smith L, Colley H, Thornhill M, Murdoch C, Smallwood R, Matcher S, MacNeil S. Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies.  Oral Diseases. 16(6):518-518 (2010) doi: 10.1111/j.1601-0825.2010.01743.x)

Sarker P, Shepherd J, Swindells K, Douglas I, MacNeil S, Swanson L, Rimmer S. Highly Branched Polymers with Polymyxin End Groups Responsive to Pseudomonas aeruginosa. Biomacromolecules 2011, 12, 1–5  (2010) (doi: 10.1021/bm100922j)

Greenwood PDL, Childs DTD, Kennedy K, Groom KM, Hugues M, Hopkinson M, Hogg RA, Krstajic N, Smith LE, Matcher SJ, Bonesi M, MacNeil S and Smallwood R. Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Device Engineering. IEEE Journal of Selected Topics in Quantum Electronics. 16(4):1015-1022. (2010) (doi: 10.1109/JSTQE.2009.2038720)

Krstajic N, Smith LE, Matcher SJ, Childs DTD, Bonesi M, Greenwood PDL, Hugues M, Kennedy K, Hopkinson M, Groom KM, MacNeil S, Hogg RA and Smallwood R. Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Skin Imaging. IEEE Journal of Selected Topics in Quantum Electronics. 16(4):748-754. (2010) (doi: 10.1109/JSTQE.2009.2038597)

Smith LE, Smallwood R and MacNeil S. A Comparison of Imaging Methodologies for 3D Tissue Engineering. Microscopy Research and Technique. Microscopy Research and Technique. 73(12):1123–1133 (2010). (doi: 10.1002/jemt.20859)

Smith LE, Bonesi M, Smallwood R, Matcher SJ and MacNeil S. Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue engineered skin. Journal of Tissue Engineering and Regenerative Medicine.  4(8):652-658 (2010) (doi: 10.1002/term.281)

Murdoch C, Reeves KJ, Hearnden V, Colley H, Massignani M, Canton I, Madsen J, Blanazs A, Armes SP, Lewis AL, MacNeil S, Brown NJ, Thornhill MH and Battaglia G.  Internalization and biodistribution of polymersomes into oral squamous cell carcinoma cells in vitro and in vivo. Nanomedicine 5(7):1025–1036. (2010) (doi: 10.2217/nnm.10.97)

Deshpande P, McKean R, Blackwood KA, Senior RA, Ogunbanjo A, Ryan AJ, MacNeil S. Using poly(lactide-co-glycolide) electrospun scaffolds to deliver cultured epithelial cells to the cornea. Regen Med. 5(3):395-401. (2010). (doi: 10.2217/rme.10.16)

Canton I, Cole DM, Kemp EH, Watson PF, Chunthapong J, Ryan AJ, MacNeil S and Haycock J. Development of a 3D human in vitro skin co-culture model for detecting irritants in real-time.  Biotechnology and Bioengineering. 106(5):794–803 (2010). (doi: 10.1002/bit.22742)

Johnson C, Perlin L, Wyman P, Zhao B, Fullwood NJ, MacNeil S, Rimmer S.  Cell Adhesion to Polymethacrylate Networks Prepared by Photopolymerization and Functionalized with GRGDS Peptide or Fibrinogen.  Macromol. Symp. 314-325 (2010). (doi: 10.1002/masy.201050537)

Picard C, Hearnden V, Massignani M, Battaglia G, MacNeil S and Donald A.  A micro-incubator for cell and tissue imaging. Biotechniques 48(2):135-138 (2010). (doi: 10.2144/000113245)

Walter MMN, Wright KT, Fuller HR, MacNeil S and Johnson WEB. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays.  Experimental Cell Research 316(7):1271-1281 (2010). (doi: 10.1016/j.yexcr.2010.02.026)

Massignani M, Canton I, Sun T, Hearnden V, MacNeil S, Blanazs A, Armes SP, Lewis A and Battaglia G. Enhanced Fluorescence Imaging of Live Cells by Effective Cytosolic Delivery of Probes. PLoS ONE 5(5): e10459. doi:10.1371/journal.pone.0010459 (2010) (doi: 10.1371/journal.pone.0010459)

Bullock AJ, Pickavance P, Haddow DB, Rimmer S and MacNeil S. Development of a calcium chelating hydrogel for treatment of superficial burns and scalds. Regenerative Medicine 5(1):55-64.  (2010) (doi: 10.2217/rme.09.67)

Green N, Huang Q, Khan L, Battaglia G, Corfe B, MacNeil S and Bury J. The development and characterisation of an organotypic tissue engineered human oesophageal model. Tissue Eng A 16(3): 1053-1064. (2010) (doi: 10.1089/ten.TEA.2009.0217)

Shepherd J, Sarker P, Douglas I, MacNeil S, Swanson L, Rimmer S and Swindells K. Binding bacteria to highly branched poly(N-isopropyl acrylamide) modified with vancomycin induces the coil-to-globule transition. Journal of the American Chemical Society 132(6): 1736-+   (2010) (doi: 10.1021/ja907466y)

Canton I, McKean R, Charnley M, Blackwood KA, Fiorica C, Ryan AJ and MacNeil S.  Development of an ibuprofen-releasing biodegradable PLA/PGA electrospun scaffold for tissue regeneration.  Biotechnology & Bioengineering 105(2): 396-408. (2010) (doi: 10.1002/bit.22530)

Adra S, Sun T, MacNeil S, Holcombe M, Smallwood R.  Development of a Three Dimensional Multiscale Computational Model of the Human Epidermis. PLoS One. 5(1)   Article Number: e8511. (2010) (doi: 10.1371/journal.pone.0008511)